is a comprehensive homeopathic HPA axis formula combining 21 active homeopathic ingredients, including Adrenalinum, Cortisone Aceticum, DHEA, Melatonin, Testosterone, Glandula Suprarenalis Suis, Hypophysis Suis, Hypothalamus Suis, Corticotropin Releasing Hormone (CRH), Adrenocorticotrophin (ACTH), Aldosterone, and seven classical constitutional remedies, prepared across multiple X and C potencies for the temporary relief of symptoms related to circadian rhythm imbalances including overuse of stimulants, anxiousness, sleep disturbances, circulatory imbalances, decreased sex drive, and salt cravings.

The hypothalamic-pituitary-adrenal (HPA) axis is not a single organ, it is a coordinated three-gland communication cascade that governs the body's entire stress response, circadian rhythm, sleep-wake cycle, sex hormone production, immune regulation, cardiovascular tone, electrolyte balance, and metabolic stability. When this cascade becomes dysregulated, the symptoms are not isolated to one system. They show up simultaneously as fatigue, sleep disruption, anxious overactivation, depleted libido, salt and stimulant cravings, poor circulation, and the general sense that the body's daily rhythm has lost its anchor.

HPAxis is one of the most comprehensive HPA axis homeopathic formulas available. What makes it clinically distinctive among DesBio's adrenal product line is its inclusion of homeopathic preparations of the actual signaling molecules of the HPA cascade: Corticotropin Releasing Hormone (CRH) from the hypothalamus, Adrenocorticotrophin (ACTH) from the pituitary, and Aldosterone from the adrenal cortex, alongside homeopathic organ sarcods (Hypothalamus Suis, Hypophysis Suis, Glandula Suprarenalis Suis) and homeopathic preparations of the major adrenal hormones (Cortisone Aceticum, DHEA, Testosterone, Adrenalinum). This approach addresses the entire axis rather than just the adrenal glands in isolation, making HPAxis particularly relevant for clients with complex HPA dysregulation involving circadian rhythm disruption, hormonal depletion, and the interconnected symptoms that reflect system-wide dysregulation.

This is a homeopathic preparation, formulated according to traditional homeopathic principles. Statements are based on traditional homeopathic practices. 1 fl oz sublingual dropper bottle.

Key Benefits:

• Provides temporary relief of symptoms related to circadian rhythm imbalances
• Addresses the full HPA axis cascade including hypothalamus, pituitary, and adrenal signaling layers
• Provides temporary relief of symptoms related to overuse of stimulants
• Provides temporary relief of anxiousness related to HPA axis dysregulation
• Supports temporary relief of sleep disturbances related to circadian rhythm imbalance
• Supports temporary relief of circulatory imbalances associated with HPA dysregulation
• Supports temporary relief of decreased sex drive related to adrenal and hormonal depletion
• Supports temporary relief of salt cravings associated with aldosterone and adrenal dysfunction
• 21 active homeopathic ingredients covering hormonal, glandular, constitutional, and signaling layers
• Includes CRH, ACTH, and Aldosterone as homeopathic signaling molecule preparations
• Non-habit forming, non-sedating, can be used alongside other medications under practitioner guidance
• Sublingual drop format for rapid mucosal absorption and flexible dosing

Active Homeopathic Ingredients:Argentum Nitricum — 6X — Associated in homeopathic tradition with anxiety, anticipatory stress, and nervous system overactivation related to adrenal and HPA excess.

Berberis Vulgaris — 6X — Associated with decreased sex drive and adrenal-hormonal symptom patterns in homeopathic tradition.

Iodium — 6X — Associated with decreased sex drive and thyroid-adrenal axis symptoms in homeopathic tradition.

Kali Carbonicum — 6X — Associated with salt cravings and the depleted, cold constitution of adrenal insufficiency in homeopathic tradition.

Natrum Muriaticum — 6X, 12X, 18X, 24X, 30X — A classical sodium-related homeopathic remedy associated with overuse of stimulants, salt cravings, and the retained, held-in emotional pattern of chronic HPA overactivation.

Adrenalinum — 8X, 12X, 18X, 24X, 30X — Homeopathic preparation of adrenaline across five potencies, supporting adrenal signaling and circadian rhythm symptom patterns.

Cortisone Aceticum — 8X, 12X, 18X, 24X, 30X — Homeopathic preparation of cortisone acetate addressing adrenal cortex hormonal signaling and anxiety-related HPA symptoms.

DHEA (Dehydroepiandrosterone) — 8X, 12X, 18X, 24X, 30X — Homeopathic preparation of DHEA, the adrenal androgen that declines with chronic stress and adrenal depletion, associated with sleep disturbances and decreased vitality.

Glandula Suprarenalis Suis — 8X, 12X, 18X, 24X, 30X — Homeopathic sarcod of the adrenal gland providing direct adrenal organ signaling support across five potencies.

Hypophysis Suis — 8X, 12X, 18X, 24X, 30X — Homeopathic sarcod of the pituitary gland providing direct pituitary signaling support, associated with overuse of stimulants in this formula.

Hypothalamus Suis — 8X, 12X, 18X, 24X, 30X — Homeopathic sarcod of the hypothalamus providing direct hypothalamic signaling support, associated with decreased sex drive in this formula.

Melatonin — 8X, 12X, 18X, 24X, 30X — Homeopathic preparation of melatonin across five potencies supporting circadian rhythm and sleep disturbance symptom patterns.

Testosterone — 8X, 12X, 18X, 24X, 30X — Homeopathic preparation of testosterone supporting decreased sex drive and hormonal depletion symptom patterns.

Arsenicum Album — 12X — A classical homeopathic remedy frequently indicated for anxiety, restlessness, and the depleted-anxious constitutional state of HPA dysregulation.

Phosphorus — 12X — A classical homeopathic constitutional remedy associated with nervous system sensitivity and exhaustion in homeopathic tradition.

Proteus (Vulgaris) — 12X — A bowel nosode associated with circulatory support in homeopathic tradition.

Sepia — 12X — A classical homeopathic remedy particularly indicated for hormonal depletion, adrenal exhaustion, and anxiety in women, with strong correspondence to the depleted-hormonal constitutional state.

Silicea — 12X — A classical homeopathic remedy associated with salt cravings and the depleted, deficient constitutional state.

Alloxanum — 18X — Associated with circulatory support in homeopathic tradition.

Corticotropin Releasing Hormone (CRH) — 12C, 18C, 24C, 30C — Homeopathic preparation of the hypothalamic hormone that initiates the HPA cascade by signaling the pituitary to release ACTH. Associated with circadian rhythm support in this formula.

Adrenocorticotrophin (ACTH) — 15C, 18C, 24C, 30C — Homeopathic preparation of the pituitary hormone that signals the adrenal cortex to produce cortisol. Associated with overuse of stimulants symptom patterns in this formula.

Aldosterone — 15C, 18C, 24C, 30C — Homeopathic preparation of the adrenal mineralocorticoid hormone that regulates sodium, potassium, and fluid balance. Associated with sleep problems in this formula, reflecting the circadian variation of aldosterone secretion that is disrupted in HPA dysregulation.

Inactive Ingredients: Demineralized water, 25% ethanol.

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Storage

Store at room temperature away from direct sunlight, strong electromagnetic fields, and strong aromatic substances including mint. Keep out of reach of children.

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Directions

One to ten drops under the tongue three times daily, or as directed by your healthcare professional. For best results take 20 minutes away from food and mint. Consult a physician before use in children under 12 years of age.

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