SLK Polyclonal Antibody

Catalogue Numbers: BS2137-50, BS2137-100

Sizes: 50µl, 100µl

Product: Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

Swiss-Prot: Q9H2G2

Host: Rabbit

Reactivity: Human, Mouse, Rat

Applications: WB

All Applications: WB: 1:500~1:1000

Background: SLK (Ste20-like kinase), also known as STK2 (serine/threonine protein kinase 2) or se20-9, is a member of the serine/threonine kinase subfamily, Ste20. This subfamily is comprised of several mammalian kinases which exhibit sequence similarity to the Saccharomyces cerevisiae serine/threonine kinase Ste20, a protein involved in relaying signals from G protein-coupled receptors to cytosolic MAP kinase cascades. Members of this subfamily include KHS, GLK, YSK1, HPK1, Krs-1, Krs-2, GC kinase, HGK and SLK. SLK is a ubiquitously expressed protein that localizes to the cytoplasm and contains an N-terminal protein kinase domain, a central coiled-coil domain and a C-terminal ATH domain. SLK is activated through cleavage by caspase-3. SLK indirectly associates with microtubules and plays an important role in cellular stress, cell motility, cell death and cytoskeletal dynamics.

Purification and Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SLK polyclonal antibody detects endogenous levels of SLK protein.

Extra Notes: Western blot (WB) analysis of SLK polyclonal antibody at 1:500 dilution
Lane1:HCT116 whole cell lysate(40ug)
Lane2:THP-1 whole cell lysate(20ug)
Lane3:The Heart tissue lysate of Rat(40ug)
Lane4:The Heart tissue lysate of Mouse(40ug)
Lane5:LOVO whole cell lysate(20ug)

Bioworld Molecular Weight: ~ 220 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: STE20-like serine/threonine-protein kinase; STE20-like kinase; hSLK; CTCL tumor antigen se20-9; STE20-related serine/threonine-protein kinase; STE20-related kinase; Serine/threonine-protein kinase 2; SLK; KIAA0204; STK2

Immunogen: Synthetic peptide, corresponding Human SLK.

Conjugate: Unconjugated

Modification: Unmodified