SMYD1 Monoclonal Antibody

Catalogue Numbers: MB66489-50, MB66489-100

Sizes: 50µl, 100µl

Product: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.

Swiss-Prot: D4A3D2

Host: Mouse

Reactivity: Rat

Applications: WB

All Applications: WB (1/500 - 1/1000)

Background: SMYD1 (SET and MYND domain-containing protein 1), also known as BOP, ZMYND18 or ZMYND22, is a nuclear and cytoplasmic protein that contains one SET domain and one MYND-type zinc finger. Expressed specifically in cardiac and skeletal muscle, SMYD1 functions as a transcription factor that is essential for cardiac morphogenesis and proper cardiomyocyte differentiation. SMYD1 interacts with the histone deacetylases HDAC1, HDAC2 and HDAC3 and, through this interaction, acts as a histone deacetylase-dependent transcriptional repressor. Defects or deletions in the gene encoding SMYD1 lead to retarded maturation of ventricular cardiomyocytes, further implicating SMYD1 as a crucial component of normal cardiac development.

Purification and Purity: The antibody was purified by immunogen affinity chromatography.

Storage and Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Recognizes endogenous levels of SMYD1 protein.

Extra Notes: Western blot analysis of SMYD1 expression in rat skeletal muscle (A) whole cell lysates.

Bioworld Molecular Weight: ~ 57 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Name: Histone-lysine N-methyltransferase SMYD1; SET and MYND domain-containing protein 1

Immunogen: Purified recombinant human SMYD1 protein fragments expressed in E.coli.

Conjugate: Unconjugated

Modification: Unmodified