(S)-AMPA (L-AMPA), an active S-enantiomer of AMPA, is a potent and selective AMPA receptor agonist.

Product information

CAS Number: 83643-88-3

Molecular Weight: 186.17

Formula: C7H10N2O4

Chemical Name: (2S)-2-amino-3-(5-methyl-3-oxo-2, 3-dihydro-1, 2-oxazol-4-yl)propanoic acid

Smiles: CC1ONC(=O)C=1C[C@H](N)C(O)=O

InChiKey: UUDAMDVQRQNNHZ-YFKPBYRVSA-N

InChi: InChI=1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

Superfusion of (S)-AMPA (1 μM) significantly attenuates CGRP release in a CB1-dependent manner. 24-h exposure to (S)-AMPA (0.01-1000 μM) induces concentration-dependent neuronal cell death (EC50 of 3 μM) with cellular changes including neurite blebbing, chromatin condensation, and DNA fragmentation, indicative of apoptosis.

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