1-(1-Naphthyl) piperazine (1-NP) is a serotonergic ligand which could bind nonselectively with multiple serotonin (5-HT) receptors . The serotonin receptors, also known as 5-HT receptors, belong to a family of G protein-coupled receptors (GPCRs) and ligand-gated ion channels (LGICs) found in the central and peripheral nervous systems. The serotonin receptors have been involved in many biological and neurological processes, such as aggression, anxiety, cognition, learning, memory, and mood . In vitro: 1-NP binds to human 5- HT6 (h5-HT6) serotonin receptors with a Ki of 120 nM . In rat cortical membranes, 1-NP inhibited the activity of 5-HT1 and 5-HT2 with IC50 values of 6 and 1 nM, respectively. 1-NP also blocked contraction in the rat fundus induced by either 5-HT or tryptamine with an IC50 of 1 nM . In vivo: In squirrel monkeys, 1-NP (0.3–1.0 mg/kg) blocked the decrease of responding under fixed-interval (FI) schedules of presentation of food caused by DOB (0.01–0.3 mg/kg), an agonist of 5-HT2. 1-NP also antagonized the decreases in responding produced by quipazine (0.1–5.6 mg/kg), another agonist with predominant 5-HT2 actions .

Product information

CAS Number: 104113-71-5

Molecular Weight: 248.75

Formula: C14H17ClN2

Chemical Name: 1-(naphthalen-1-yl)piperazine hydrochloride

Smiles: Cl.C1CN(CCN1)C1=CC=CC2C=CC=CC=21

InChiKey: ZYVYPNZFOCZLEM-UHFFFAOYSA-N

InChi: InChI=1S/C14H16N2.ClH/c1-2-6-13-12(4-1)5-3-7-14(13)16-10-8-15-9-11-16;/h1-7,15H,8-11H2;1H

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

Products are for research use only. Not for human use.