Neurokinin antagonist 1 is a Neurokinin antagonist extracted from patent WO1998045262A1.

Product information

CAS Number: 214487-45-3

Molecular Weight: 600.75

Formula: C38H40N4O3

Chemical Name: N-[(1R,2S)-2-[(2R)-2-[N-methyl-2-(4-methylphenyl)acetamido]-3-(naphthalen-2-yl)propanamido]cyclohexyl]-1H-indole-3-carboxamide

Smiles: CC1C=CC(CC(=O)N(C)[C@H](CC2=CC3=CC=CC=C3C=C2)C(=O)N[C@H]2CCCC[C@H]2NC(=O)C2=CNC3C=CC=CC=32)=CC=1

InChiKey: JXDKAWGCUBTYFX-GVBYMILNSA-N

InChi: InChI=1S/C38H40N4O3/c1-25-15-17-26(18-16-25)23-36(43)42(2)35(22-27-19-20-28-9-3-4-10-29(28)21-27)38(45)41-34-14-8-7-13-33(34)40-37(44)31-24-39-32-12-6-5-11-30(31)32/h3-6,9-12,15-21,24,33-35,39H,7-8,13-14,22-23H2,1-2H3,(H,40,44)(H,41,45)/t33-,34+,35-/m1/s1

Technical Data

Appearance: Solid Power

Purity: ≥98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis

Storage Condition: Dry, dark and -20 ^oC for 1 year or refer to the Certificate of Analysis.

Shelf Life: ≥12 months if stored properly.

Stock Solution Storage: 0 - 4 ^oC for 1 month or refer to the Certificate of Analysis.

Drug Formulation: To be determined

HS Tariff Code: 382200

How to use

In Vitro:

The invention in the patent WO1998045262A1 refers to antagonists of the interaction between the P substance and the NK-1 receptor, the process for their preparation, and their use in pharmaceutical compositions which may be used in the treatment of pathological forms in which the P substance receptor is involved, and in particular in the treatment of the inflammation of airways, such as asthma and rhinitis, and in the treatment of emesis.

Products are for research use only. Not for human use.