Recombinant Mouse 4-1BB/TNFRSF9 Protein (aa 24-187, Fc Tag)(Active)

Sizes: 10μg, 50μg

Catalogue Numbers: PKSM041199-10, PKSM041199-50

Citations, Manuals and MSDS Available upon request.

Abbreviation: 4-1BB; TNFRSF9

Target Symptom: 4-1BB; A930040I11Rik; AA408498; AI325004; Cd137; CDw137; ILA; Ly63; Secreted CD137 antigen; Tumor necrosis factor receptor superfamily member 9; Tnfrsf9

Target Species: Mouse

Expression Host: HEK293 Cells

Application: ELISA

Fusion Tag: C-Fc

Accession: NP_001070976.1

Background: Tumor necrosis factor receptor superfamily member 9(TNFRSF9) is a member of the tumor necrosis factor (TNF) receptor family. It can be induced by lymphocyte activation (ILA) and is expressed by activated T cells, but to a larger extent on CD8 than on CD4 T cells. In addition, TNFRSF9 expression is found on dendritic cells, follicular dendritic cells, natural killer cells, granulocytes and cells of blood vessel walls at sites of inflammation. As receptor for TNFSF9/4-1BBL, it can activate T cells and the cross-linking of this protein can enhance T cell proliferation, IL-2 secretion survival and cytolytic activity. Further, it can enhance immune activity to eliminate tumors in mice.

Activity: Immobilized Human 4-1BBL-His(Cat: PKSH032023) at 0.05μg/ml(100 μl/well) can bind Mouse 4-1BB-Fc.

Sequence: Val24-Leu187

Purity: > 95 % as determined by reducing SDS-PAGE.

Formulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Reconstitution: Not Applicable

Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method.

Calculated MW: 44.7 kDa

Observed MW: 60-70 kDa

Storage: Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.

Shipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.

Research Use Only